Prof Dariusz Leszczynski public lecture on Effects of Mobile Phone Radiation on Human Endothelium
Prof Dariusz Leszczynski, PhD, DSc Adjunct Professor of Biochemistry, University of Helsinki, Finland, Chief Editor of ‘Radiation and Health’, Lausanne, Switzerland
About Prof Dariusz Leszczynski’s Lecture
Several animal studies suggested that mobile phone radiation may cause leakage of the blood-brain barrier. Studies of my research group, using cultures of human endothelial cell line, have shown that mobile phone radiation, at levels permitted by the current safety standards, activates Hsp27/p38MAP kinase stress response pathway.
Exposure of endothelial cells to mobile phone radiation caused transient increase in phosphorylation (activity) of the Hsp27 stress protein and p38MAP kinase. Activation of the Hsp27/p38MAPK pathway led to re-distribution of the F-actin in cytoplasm and an increased stability of the F-actin stress fibers. This, in turn, led to shrinkage of the endothelial cells.
These observations suggest that mobile phone radiation might affect endothelial permeability and potentially cause leakage of the blood-brain barrier.
Furthermore, it is likely that the activation of the Hsp27/p38MAPK pathway affects also endothelial gene expression, as shown by the analysis of changes in expression of endothelial transcriptome and proteome.
The only human volunteer proteomic study, performed by my research group, has indicated that mobile phone radiation might alter protein expression in human skin.
Further studies are necessary to determine whether changes of transcriptome, proteome and bloodbrain barrier permeability are caused by mobile phone radiation in human brain.
Prof Dariusz Leszczynski’s Lecture – WHEN and WHERE
Melbourne University, Friday, 11th December, 2015, at 2.00PM
Richard Newton Rooms, Level 5, Electrical Engineering Building, University of Melbourne
Prof Dariusz Leszczynski’s Lecture – HOW
RSVP to Fiorella [email protected]